LARGE LIBRARIES OF SINGLE-CHAIN TRIMER PEPTIDE-MHCS ENABLE ANTIGEN-SPECIFIC CD8+ T CELL DISCOVERY AND ANALYSIS

Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis

Abstract The discovery and characterization of antigen-specific CD8+ Lunchbox T cell clonotypes typically involves the labor-intensive synthesis and construction of peptide-MHC tetramers.We adapt single-chain trimer (SCT) technologies into a high throughput platform for pMHC library generation, showing that hundreds can be rapidly prepared across m

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Turning the Tide: Natural Products and Natural-Product-Inspired Chemicals as Potential Counters to SARS-CoV-2 Infection

The novel and highly pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), has become a continued focus of global attention due to the Zester serious threat it poses to public health.There are no specific drugs available to combat SARS-CoV-2 infection.Natural products (carolacton,

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